The most relevant applications were ordered by the constitutes to be analysed. Moreover, the latest research progress of SFC applications in medicinal plant analyses is illuminated, with a focus on herbal medicine-related SFC papers at the analytical and preparative scale that were published during the period of 2012 to December 2018. This work aims to give a comprehensive overview of the fundamentals, technical advancement and investigating parameters of SFC in combination with three prevalent detectors. In recent years, the advent of new-generation supercritical fluid chromatography (SFC) instruments and a wide diversity of column chemistries, coupled with the intrinsic technical features of SFC, have made it an alternative and prominent analytical platform in the medicinal plant research area. Fortunately, the advancement of various emerging techniques has provided potent support for improving the method selectivity, sensitivity and run speeds in medicinal plants analyses. The separation, quantification, characterization and purification of bioactive components from herbal medicine extracts have always challenged analysts. Based on SSI’s demonstrated success in the development of analytical and measuring instruments, technical expertise, resources, timeliness and collaborative spirit, through an open RFP process, ETC selected SSI as its dedicated partner to develop and commercialize this improved SFC system.Medicinal plants with complex matrices are endowed with a wide scope of biological activities. “Their insight into what’s truly needed by the industry drove this project forward, and we are very grateful for the opportunity to work with such an amazing team.”ĮTC is a forum for pharmaceutical and biotechnology companies to discuss ideas, share information and collaborate on the development of new enabling technologies. “Working with the Enabling Technologies Consortium, and hearing the voice of the pharmaceutical industry, has been an incredibly valuable learning experience for us at Shimadzu,” said Patrick Fromal, VP Sales, Shimadzu Scientific Instruments. “This new generation system provides improved hardware and software features that answer the pharmaceutical industry’s demand for an efficient and robust prep SFC system.” “The Nexera Prep SFC System is an improved purification instrumentation that meets the specifications and requirements from SFC users across the pharmaceutical industry,” said Mirlinda Biba, PhD, Principal Scientist, Merck & Co. Moreover, the elegant design of the new gas-liquid separator reduces the total size of the recovery system and allows for easy rinsing compared to earlier cyclone-style or centrifugal type GLS systems. Importantly, the newly designed gas-liquid separator realizes a higher recovery ratio and lower carryover than earlier SFC systems. Innovative technologies include a flexible format combination injector/fraction collector, CO2 pump with integrated chiller that requires less lab space and allows for benchtop use, a novel gas-liquid separator design to ensure high recovery and low carryover, and easy-to-use preparative software to streamline operations. This complete SFC solution reduces the need for costly and hazardous solvents used in normal phase prep LC, while shortening purification run time and dry down time. Each Nexera UC semi-prep system is configurable to user specifications in order to optimally perform the desired purification function including chiral or achiral purifications, single injections, stacked injections, and fraction collections from several microliters to liters. The platform is based around the Nexera ultra high-performance liquid chromatograph. The Nexera Semi-Prep SFC System is part of SSI’s Nexera UC platform, which accommodates a wide variety of analyses and purifications. This next-generation prep SFC system provides the pharmaceutical industry with reliable high-performance semi-prep purification. Shimadzu Scientific Instruments (SSI), in partnership with the Enabling Technologies Consortium™ (ETC), announces the release of the Nexera Preparative Supercritical Fluid Chromatography System.
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